Comprehensive study for the development of rectal suppositories with diosmin and hesperidin

The aim. To conduct a comprehensive study of biphasic-type suppositories that contain diosmin and hesperidin.
 Materials methods. Samples with mass 4.0 were objects the study. Pharmacological, technological analytical research methods used to directly or indirectly analyze strength completeness drug activity. Thus, in this work we combined specificity pharmacological action drug, experimental verification quantitative content API, analysis structural properties profile release active pharmaceutical ingredients.
 Results. Therefore, based on obtained data, most effective dose was 75 mg / kg (in terms human 300 per suppository). selected showed significant therapeutic effect, which significantly exceeded test sample at lower reference agent. According results studies, it determined all samples had satisfactory mechanical properties. Studies histological structure mucous membrane rats proved there is positive effect treatment hesperidin due improvement normal condition membrane, absence edema ulcerative defect. Research ingredients best percentage characteristic 2 (99.8 %)
 Conclusions. therapeutically mg/kg animal weight can be for further will interest hemorrhoids both acute chronic forms